An investigation into multi-spectral excitation power sources for Electrical Impedance Tomography

Electrical Impedance Tomography is a non-invasive, non-ionizing, non-destructive and painless imaging technology that can distinguish between cancerous and non-cancerous cells by reproducing tomographic images of the electrical impedance distribution within the body. The primary scope of this thesis is the study of hardware modules required for an EIT system. The key component in any EIT system is the excitation system. Impedance measurement can be performed by applying either a current or voltage through emitting electrodes and then measuring the resulting voltages or current on receiving electrodes. In this research, both types of excitation systems are investigated and developed for the Sussex EIM system. Firstly, a current source (CS) excitation system is investigated and developed. The performance of the excitation system degrades due to the unwanted capacitance within the system. Hence two CS circuits: Enhance Howland Source (EHS) and EHS combined with a General impedance convertor (GIC: to minimise the unwanted capacitance) are evaluated. Another technique (guard-amplifier) has also been investigated and developed to minimise the effect of stray capacitance. The accuracy of both types of CS circuits are evaluated in terms of its output impedance along with other performance parameters for different loading conditions and the results are compared to show their performance. Both CS circuits were affected by the loading voltage problem. A bootstrapping technique is investigated and integrated with both CS circuits to overcome the loading voltage problem. The research shows that both CS circuits were unable to achieve a high frequency bandwidth (i.e. ≥10MHz) and were limited to 2-3MHz. Alternatively, a discrete components current source was also investigated and developed to achieve a high frequency bandwidth and other desirable performance parameters. The research also introduces a microcontroller module to control the multiplexing involved for different CS circuit configurations via serial port interface software running on a PC. For breast cancer diagnosis, the interesting characteristics of breast tissues mostly lie above 1MHz, therefore a wideband excitation source covering high frequencies (i.e. ≥1-10MHz) is required. Hence, a second type of the excitation system is investigated. A constant voltage source (VS) circuit was developed for a wide frequency bandwidth with low output impedance. The research investigated three VS architectures and based on their initial bandwidth comparison, a differential VS system was developed to provide a wide frequency bandwidth (≥10MHz). The research presents the performance of the developed VS excitation system for different loading configurations reporting acceptable performance parameters. A voltage measurement system is also developed in this research work. Two different differential amplifier circuits were investigated and developed to measure precise differential voltage at a high frequency. The research reports a performance comparison of possible types of excitation systems. Results are compared to establish their relationship to performance parameters: frequency bandwidth, output impedance, SNR and phase difference over a wide bandwidth (i.e. up to 10MHz). The objective of this study is to investigate which design is the most appropriate for constructing a wideband excitation system for the Sussex EIM system or any other EIT based biomedical application with wide a bandwidth requirement

Validity of using the Sheffield algorithm for the Sussex EIT MK4

This paper introduces the image reconstruction algorithm from Sheffield group and the validity of this algorithm to the Sussex MK4

Converting EIT voxel based imaging and pixel based ultrasound imaging to standardised DICOM

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Investigation of voltage source designs for Electrical Impedance Mammography Systems

According to Jossient, interesting characteristics of breast tissues mostly lie above 1MHz [1]; therefore a wideband excitation source covering higher frequencies (i.e. above 1MHz) is required. The main objective of this research is to establish a feasible bandwidth envelope that can be used to design a constant EIM voltage source over a wide bandwidth with low output impedance for practical implementation. An excitation source is one of the major components in bio-impedance measurement systems. In any bio-impedance measurement system the excitation source can be achieved either by injecting current and measuring the resulting voltages, or by applying voltages and measuring the current developed. This paper describes three voltage source architectures and based on their bandwidth comparison; a differential voltage controlled voltage source (VCVS) is proposed, which can be used over a wide bandwidth (>15MHz). This paper describes the performance of the designed EIM voltage source for different load conditions and load capacitances reporting signal-to-noise ratio of approx 90dB at 10MHz frequency, signal phase and maximum of 4.75kΩ source output impedance at 10MHz. Optimum data obtained using Pspice® is used to demonstrate the high-bandwidth performance of the source

Multi-frequency response mesh phantom for validation of EIT system performance

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An electrical mesh phantom for the planar structure EIT systems

Evaluation of planar EIT systems used in clinical studies can be based on a realistic electronic phantom (E-phantom). This paper describes a mesh phantom based on an 85 electrode planar mesh structure. The design presents a dynamic mesh phantom to assess the performance of the planar topology to simulate in vivo conditions. The phantom is especially designed for the Sussex EIT system to validate system measurements